The geography of networks and RD collaborations, in particular the spatial dimension of interactions between organisations performing joint RD, have attracted a burst of attention in the last decade, both in the scientific study of the networks and in the policy sector. The volume is intended to bring together a selection of articles providing novel theoretical and empirical insights into the geographical dynamics of such networks and RD collaborations, using new, systematic data sources and employing cutting-edge spatial analysis and spatial econometric techniques. It comprises a section on analytic advances and methodology and two thematic sections on structure and spatial characteristics of RD networks and the impact of RD networks and policy implications. The edited volume provides a collection of high-level research contributions with an aim to contribute to the recent debate in economic geography and regional science on how the structure of formal and informal networks modifies and influences the spatial and temporal diffusion of knowledge.